Etiology and Pathogenesis of Unicystic Ameloblastoma Based on The Histopathology Examination Result Analysis
Abstract
Unicystic ameloblastoma is a type of ameloblastoma that often occurs at a young age. Unicystic ameloblastoma can occur due to neoplastic transformation from an odontogenic cyst to an odontogenic tumor, ameloblastic transformation of reduced enamel epithelium from developing teeth, or cystic degeneration of solid ameloblastoma. However, there is no convincing evidence has yet been found for each proposed pathogenesis. This study aims to determine the development of etiology and pathogenesis of unicystic ameloblastoma based on the analysis of the results of histopathological examination. This study aims to determine the development of etiology and pathogenesis of unicystic ameloblastoma based on the analysis of the results of histopathological examination. The study was conducted using a systematic review method through searching journals on PubMed, Google Scholar and Scopus using keywords. In the initial search, 1109 journals were obtained, which were then selected based on inclusion criteria, namely English-language journals published in 2017-2020, indexed in Scopus, and relating to the etiology and pathogenesis of unicystic ameloblastoma based on the analysis of the results of histopathological examination, so that 16 journals were obtained. Etiology of the unicystic ameloblastoma has not undergone renewal, and the currently known pathogenesis of the unicystic ameloblastoma is molecular pathogenesis, namely where the development of odontogenic lesions occurs due to pathogenic gene mutations that affect the signaling pathway. The mutation that often occurs is the BRAF V600E mutation which is included in the MAPK signaling pathway.
References
Figueiredo NR, Dinkar AD, Meena M, Satoskar S, Khorate M. Ameloblastoma: A clinicoradiographic and histopathologic correlation of 11 cases seen in Goa during 2008-2012. Contemp Clin Dent. 2014 Apr 1;5(2):160–5.
Parmar S, Al-Qamachi L, Aga H. Ameloblastomas of the mandible and maxilla. Curr Opin Otolaryngol Head Neck Surg. 2016;24(2):148–54.
Sham E, Leong J, Maher R, Schenberg M, Leung M, Mansour AK. Mandibular ameloblastoma: Clinical experience and literature review. ANZ J Surg [Internet]. 2009 Oct 1 [cited 2019 Jun 19];79(10):739–44. Available from: http://doi.wiley.com/10.1111/j.1445-2197.2009.05061.x.
Mulia VD. Sitologi Tumor Odontogenik: Ameloblastoma. Cakradonya Dent J. 2015;7(2):807–68.
Ueno S. A clinicopathologic study of ameloblastoma. Obstet Gynecol [Internet]. 2013;122(6):1223–30. Available from: http://dx.doi.org/10.1016/S0278-2391(86)80031-3
Effiom OA, Ogundana OM, Akinshipo AO, Akintoye SO. Ameloblastoma: current etiopathological concepts and management. Oral Dis. 2018;24(3):307–16.
Cahyawati TD. Ameloblastoma. J Kedokt Unram. 2018;7(1):19–25.
Laborde A, Nicot R, Wojcik T, Ferri J, Raoul G. Ameloblastoma of the jaws: Management and recurrence rate. Eur Ann Otorhinolaryngol Head Neck Dis [Internet]. 2016;134(1):7–11. Available from: http://dx.doi.org/10.1016/j.anorl.2016.09.004
Kreshna JR, Azhari. Variasi Gambaran Ameloblastoma pada Mandibula. J Radiol Dentomaksilofasial Indones. 2019;3(1):5–10.
Nadendla LK. Unusual imaging appearance of unicystic ameloblastoma. Contemp Clin Dent. 2012;3(4):475–7.
Nagi R, Sahu S, Rakesh N. Molecular and genetic aspects in the etiopathogenesis of ameloblastoma: An update. J Oral Maxillofac Pathol [Internet]. 2016 [cited 2019 Jun 19];20(3):497–504. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27721617
Wright JM, Tekkesin MS. Odontogenic tumours: Where are we in 2017? J Istanbul Univ Fac Dent. 2017;51(3 Suppl 1):10–30.
Masthan KMK, Anitha N, Krupaa J, Manikkam S. Ameloblastoma: Review Article. J Pharm Bioallied Sci. 2015;7(April):S167–70.
Chaudhary Z, Pal U, Sangwan V, Sharma P. Unicystic ameloblastoma: A diagnostic dilemma. Natl J Maxillofac Surg. 2011;2(1):89–92.
Al Sineedi F, Aruveetil YA, Kavarodi AM, Harbi SO. Bilocular unicystic ameloblastoma of the mandible in a 9 yr old child – A diagnostic and management dilemma. Saudi Dent J [Internet]. 2018;30(3):250–5. Available from: https://doi.org/10.1016/j.sdentj.2018.03.001
Han Y, Fan X, Su L, Wang Z. Diffusion-weighted mr imaging of unicystic odontogenic tumors for differentiation of unicystic ameloblastomas from keratocystic odontogenic tumors. Korean J Radiol. 2018;19(1):79–84.
Gunawardhana KS ingappulig. ND arshan., Jayasooriya PR ukma., Tilakaratne WM udiyanselag. Diagnostic dilemma of unicystic ameloblastoma: novel parameters to differentiate unicystic ameloblastoma from common odontogenic cysts. J Investig Clin Dent. 2014;5(3):220–5.
Fatemeh M, Sepideh A, Sara BS, Nazanin M. P53 protein expression in dental follicle, dentigerous cyst, odontogenic keratocyst, and inflammatory subtypes of cysts: An immunohistochemical study. Oman Med J. 2017;32(3):227–32.
Costa V, Fregnani ER, Fonseca FP, Abreu Alves F, Pinto CAL, Kaminagakura E. EGFR is not amplified in ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125(5):454–8.
Chouinard AF, Peacock ZS, Faquin WC, Kaban LB. Unicystic Ameloblastoma Revisited: Comparison of Massachusetts General Hospital Outcomes With Original Robinson and Martinez Report. J Oral Maxillofac Surg [Internet]. 2017;75(11):2369–78. Available from: http://dx.doi.org/10.1016/j.joms.2017.03.034
Diniz MG, Gomes CC, de Sousa SF, Xavier GM, Gomez RS. Oncogenic signalling pathways in benign odontogenic cysts and tumours. Oral Oncol. 2017;72:165–73.
Peacock ZS. Controversies in Oral and Maxillofacial Pathology. Oral Maxillofac Surg Clin North Am [Internet]. 2017;29(4):475–86. Available from: https://doi.org/10.1016/j.coms.2017.06.005
Wright JM, Vered M. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors. Head Neck Pathol. 2017;11(1):68–77.
Soluk-Tekkeşin M, Wright JM. The world health organization classification of odontogenic lesions: A summary of the changes of the 2017 (4th) edition. Turkish J Pathol. 2017;34(1):1–18.
Bilodeau EA, Seethala RR. Update on Odontogenic Tumors: Proceedings of the North American Head and Neck Pathology Society. Head Neck Pathol. 2019;13(3):457–65.
Diniz MG, Guimarães BVA, Pereira NB, de Menezes GHF, Gomes CC, Gomez RS. DNA damage response activation and cell cycle dysregulation in infiltrative ameloblastomas: A proposed model for ameloblastoma tumor evolution. Exp Mol Pathol [Internet]. 2017;102(3):391–5. Available from: http://dx.doi.org/10.1016/j.yexmp.2017.04.003
Argyris PP, Malz C, Taleb R, Koutlas IG. Benign and malignant odontogenic neoplasms of the jaws show a concordant nondiscriminatory p63/p40 positive immunophenotype. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126(6):506–12.
Zaheer S, Naseem N, Nagi AH. Relative Frequency of Odontogenic Lesions Based on Their Histological Diagnosis. 2017;33(3):234–8.
Barrett AW, Sneddon KJ, Tighe J V, Gulati A, Newman L, Collyer J, et al. Dentigerous Cyst and Ameloblastoma of the Jaws: Correlating the Histopathological and Clinicoradiological Features Avoids a Diagnostic Pitfall. Int J Surg Pathol. 2017;25(2):141–7.
Embaló B, Parize HN, Rivero ERC. Evaluation of cell proliferation in cystic lesions associated with impacted third molars. Microsc Res Tech. 2018;81(11):1241–5.
do Canto AM, da Silva Marcelino BMR, Schussel JL, Wastner BF, Sassi LM, Corrêa L, et al. Immunohistochemical analysis of BRAF V600E mutation in ameloblastomas. Clin Oral Investig. 2018;23(2):779–84.
Soluk-Tekkeşin M, Wright JM. The world health organization classification of odontogenic lesions: A summary of the changes of the 2017 (4th) edition. Turk Patoloji Derg. 2018;34(1):1–18.
Muñiz-Lino MA, Rodríguez-Vázquez M, Chávez-Munguía B, Ortiz-García JZ, González-López L, Hernández-Hernández FC, et al. Establishment and characterization of a cell population derived from a dentigerous cyst. J Oral Pathol Med. 2017;46(8):603–10.
Lawal AO, Adisa AO, Olajide M. Cystic ameloblastoma: A clinico-pathologic review. Ann Ibadan Postgrad Med. 2014;12(1):49–53.
Jaafari-ashkavandi Z, Geramizadeh B, Ranjbar MA. P63 and Ki-67 Expression in Dentigerous Cyst and Ameloblastomas. J Dent (Shiraz Univ Med Sci. 2015;16(4):323–8.
Varsha BK, Gharat AL, Nagamalini BR, Jyothsna M, Mothkur ST, Swaminathan U. Evaluation and comparison of expression of p63 in odontogenic keratocyst, solid ameloblastoma and unicystic ameloblastoma. J Oral Maxillofac Pathol. 2014;18(2):223–8.
Parmar S, Al-Qamachi L, Aga H. Ameloblastomas of the mandible and maxilla. Curr Opin Otolaryngol Head Neck Surg. 2016;24(2):148–54.
Sham E, Leong J, Maher R, Schenberg M, Leung M, Mansour AK. Mandibular ameloblastoma: Clinical experience and literature review. ANZ J Surg [Internet]. 2009 Oct 1 [cited 2019 Jun 19];79(10):739–44. Available from: http://doi.wiley.com/10.1111/j.1445-2197.2009.05061.x.
Mulia VD. Sitologi Tumor Odontogenik: Ameloblastoma. Cakradonya Dent J. 2015;7(2):807–68.
Ueno S. A clinicopathologic study of ameloblastoma. Obstet Gynecol [Internet]. 2013;122(6):1223–30. Available from: http://dx.doi.org/10.1016/S0278-2391(86)80031-3
Effiom OA, Ogundana OM, Akinshipo AO, Akintoye SO. Ameloblastoma: current etiopathological concepts and management. Oral Dis. 2018;24(3):307–16.
Cahyawati TD. Ameloblastoma. J Kedokt Unram. 2018;7(1):19–25.
Laborde A, Nicot R, Wojcik T, Ferri J, Raoul G. Ameloblastoma of the jaws: Management and recurrence rate. Eur Ann Otorhinolaryngol Head Neck Dis [Internet]. 2016;134(1):7–11. Available from: http://dx.doi.org/10.1016/j.anorl.2016.09.004
Kreshna JR, Azhari. Variasi Gambaran Ameloblastoma pada Mandibula. J Radiol Dentomaksilofasial Indones. 2019;3(1):5–10.
Nadendla LK. Unusual imaging appearance of unicystic ameloblastoma. Contemp Clin Dent. 2012;3(4):475–7.
Nagi R, Sahu S, Rakesh N. Molecular and genetic aspects in the etiopathogenesis of ameloblastoma: An update. J Oral Maxillofac Pathol [Internet]. 2016 [cited 2019 Jun 19];20(3):497–504. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27721617
Wright JM, Tekkesin MS. Odontogenic tumours: Where are we in 2017? J Istanbul Univ Fac Dent. 2017;51(3 Suppl 1):10–30.
Masthan KMK, Anitha N, Krupaa J, Manikkam S. Ameloblastoma: Review Article. J Pharm Bioallied Sci. 2015;7(April):S167–70.
Chaudhary Z, Pal U, Sangwan V, Sharma P. Unicystic ameloblastoma: A diagnostic dilemma. Natl J Maxillofac Surg. 2011;2(1):89–92.
Al Sineedi F, Aruveetil YA, Kavarodi AM, Harbi SO. Bilocular unicystic ameloblastoma of the mandible in a 9 yr old child – A diagnostic and management dilemma. Saudi Dent J [Internet]. 2018;30(3):250–5. Available from: https://doi.org/10.1016/j.sdentj.2018.03.001
Han Y, Fan X, Su L, Wang Z. Diffusion-weighted mr imaging of unicystic odontogenic tumors for differentiation of unicystic ameloblastomas from keratocystic odontogenic tumors. Korean J Radiol. 2018;19(1):79–84.
Gunawardhana KS ingappulig. ND arshan., Jayasooriya PR ukma., Tilakaratne WM udiyanselag. Diagnostic dilemma of unicystic ameloblastoma: novel parameters to differentiate unicystic ameloblastoma from common odontogenic cysts. J Investig Clin Dent. 2014;5(3):220–5.
Fatemeh M, Sepideh A, Sara BS, Nazanin M. P53 protein expression in dental follicle, dentigerous cyst, odontogenic keratocyst, and inflammatory subtypes of cysts: An immunohistochemical study. Oman Med J. 2017;32(3):227–32.
Costa V, Fregnani ER, Fonseca FP, Abreu Alves F, Pinto CAL, Kaminagakura E. EGFR is not amplified in ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125(5):454–8.
Chouinard AF, Peacock ZS, Faquin WC, Kaban LB. Unicystic Ameloblastoma Revisited: Comparison of Massachusetts General Hospital Outcomes With Original Robinson and Martinez Report. J Oral Maxillofac Surg [Internet]. 2017;75(11):2369–78. Available from: http://dx.doi.org/10.1016/j.joms.2017.03.034
Diniz MG, Gomes CC, de Sousa SF, Xavier GM, Gomez RS. Oncogenic signalling pathways in benign odontogenic cysts and tumours. Oral Oncol. 2017;72:165–73.
Peacock ZS. Controversies in Oral and Maxillofacial Pathology. Oral Maxillofac Surg Clin North Am [Internet]. 2017;29(4):475–86. Available from: https://doi.org/10.1016/j.coms.2017.06.005
Wright JM, Vered M. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors. Head Neck Pathol. 2017;11(1):68–77.
Soluk-Tekkeşin M, Wright JM. The world health organization classification of odontogenic lesions: A summary of the changes of the 2017 (4th) edition. Turkish J Pathol. 2017;34(1):1–18.
Bilodeau EA, Seethala RR. Update on Odontogenic Tumors: Proceedings of the North American Head and Neck Pathology Society. Head Neck Pathol. 2019;13(3):457–65.
Diniz MG, Guimarães BVA, Pereira NB, de Menezes GHF, Gomes CC, Gomez RS. DNA damage response activation and cell cycle dysregulation in infiltrative ameloblastomas: A proposed model for ameloblastoma tumor evolution. Exp Mol Pathol [Internet]. 2017;102(3):391–5. Available from: http://dx.doi.org/10.1016/j.yexmp.2017.04.003
Argyris PP, Malz C, Taleb R, Koutlas IG. Benign and malignant odontogenic neoplasms of the jaws show a concordant nondiscriminatory p63/p40 positive immunophenotype. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126(6):506–12.
Zaheer S, Naseem N, Nagi AH. Relative Frequency of Odontogenic Lesions Based on Their Histological Diagnosis. 2017;33(3):234–8.
Barrett AW, Sneddon KJ, Tighe J V, Gulati A, Newman L, Collyer J, et al. Dentigerous Cyst and Ameloblastoma of the Jaws: Correlating the Histopathological and Clinicoradiological Features Avoids a Diagnostic Pitfall. Int J Surg Pathol. 2017;25(2):141–7.
Embaló B, Parize HN, Rivero ERC. Evaluation of cell proliferation in cystic lesions associated with impacted third molars. Microsc Res Tech. 2018;81(11):1241–5.
do Canto AM, da Silva Marcelino BMR, Schussel JL, Wastner BF, Sassi LM, Corrêa L, et al. Immunohistochemical analysis of BRAF V600E mutation in ameloblastomas. Clin Oral Investig. 2018;23(2):779–84.
Soluk-Tekkeşin M, Wright JM. The world health organization classification of odontogenic lesions: A summary of the changes of the 2017 (4th) edition. Turk Patoloji Derg. 2018;34(1):1–18.
Muñiz-Lino MA, Rodríguez-Vázquez M, Chávez-Munguía B, Ortiz-García JZ, González-López L, Hernández-Hernández FC, et al. Establishment and characterization of a cell population derived from a dentigerous cyst. J Oral Pathol Med. 2017;46(8):603–10.
Lawal AO, Adisa AO, Olajide M. Cystic ameloblastoma: A clinico-pathologic review. Ann Ibadan Postgrad Med. 2014;12(1):49–53.
Jaafari-ashkavandi Z, Geramizadeh B, Ranjbar MA. P63 and Ki-67 Expression in Dentigerous Cyst and Ameloblastomas. J Dent (Shiraz Univ Med Sci. 2015;16(4):323–8.
Varsha BK, Gharat AL, Nagamalini BR, Jyothsna M, Mothkur ST, Swaminathan U. Evaluation and comparison of expression of p63 in odontogenic keratocyst, solid ameloblastoma and unicystic ameloblastoma. J Oral Maxillofac Pathol. 2014;18(2):223–8.
Published
2024-07-31
How to Cite
HARIANTO, Azzah Aqillah; HARDIANTO, Andri; HADIKRISHNA, Indra.
Etiology and Pathogenesis of Unicystic Ameloblastoma Based on The Histopathology Examination Result Analysis.
Journal of Indonesian Dental Association, [S.l.], v. 7, n. 1, p. 33-39, july 2024.
ISSN 2621-6175.
Available at: <http://jurnal.pdgi.or.id/index.php/jida/article/view/1022>. Date accessed: 22 dec. 2024.
doi: https://doi.org/10.32793/jida.v7i1.1022.
Issue
Section
Review Article
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
