The Antifungal Potential of Stevia rebaudiana Bertoni Leaf Extract Against Candida albicans

  • Margaretha Herawati Department of Oral Biology, Faculty of Dentistry, Prof. Dr. Moestopo University, Indonesia
  • Sinta Deviyanti Department of Oral Biology, Faculty of Dentistry, Prof. Dr. Moestopo University, Indonesia
  • Adibah Ferhad Department of Oral Biology, Faculty of Dentistry, Prof. Dr. Moestopo University, Indonesia


Candida sp. are eukaryotic opportunistic pathogens that reside on the mucosa oral cavity, gastrointestinal tract, vagina and sometimes skin. An infection caused by Candida is termed candidiasis or candidosis. Oral candidiasis is a common opportunistic infection of the oral cavity caused by overgrowth of Candida species, the most common being Candida albicans. Risk factor for oral candidiasis are local factors, systemic factors and the physiological states. The most commonly used classes of antifungal drug treatment to Candida infections are the azole, polyenes and echinocandins. However, the management of Candida infections faces many problems, such as toxicity, resistance of Candida to antifungal drugs, relapse to Candida infection and the high cost of antifungal drugs. Many investigators are exploiting alternative therapeutic strategies to overcome problems treating candidiasis. Stevia leaves extracts has been known to have antifungal activity to treat candidiasis. The aim of this review article is to explain antifungal potency of Stevia rebaudiana Bertoni leaves extracts toward Candida albicans. Stevia rebaudiana Bertoni leaves extracts can use as cheap, natural and alternative agent to control candidiasis.


Carroll KC, Hobden JA, Miller S, Morse SA, Mietzer TA, Detrick B, et al. Mikrobiologi Kedokteran. Edisi 27. Jakarta: Penerbit Buku Kedokteran EGC; 2016.
Neville BW, Damm DD, Allen CM, Chi AC. Color atlas of oral and maxillofacial diseases. Philadelphia: Elsevier; 2019.
Kim J, Sudbery P. Candida albicans, a major human fungal pathogen. J Microbiol. 2011;49(2):171.
Samaranayake L. Essential microbiology for dentistry. 5th ed. Edinburgh: Elsevier Health Sciences; 2018
Haveles EB. Applied pharmacology for the dental hygienist. 8th Ed. St Louis: Elsevier; 2020.
Wray D. Essential dental therapeutics.Chichester, West Sussex: John Wiley & Sons; 2018.
Apriliana P, Arthur PK, Evy E, Abu R. Profil pasien baru kandidiasis (profile of new patients of candidasis). Berkala Ilmu Kesehatan Kulit dan Kelamin – Periodical of Dermatology and Venereology. 2019;31(1):24-34.
Martins N, Ferreira IC, Barros L, Silva S, Henriques M. Candidiasis: predisposing factors, prevention, diagnosis and alternative treatment. Mycopathologia. 2014;177(5-6):223-40.
Mandras N, Nostro A, Roana J, Scalas D, Banche G, Ghisetti V, et al. Liquid and vapour-phase antifungal activities of essential oils against Candida albicans and non-albicans Candida. BMC complement altern med. 2016;16(1):330.
Mittal S, Hiregoudar M, Subramaniam R, Muralikrishna KS, Sakeenabi B, Prashant GM, et al. Dental effect of three herbal extracts against Streptococcus mutans and Lactobacillus acidophilus in comparison to chlorhexidine. J Indian Assoc Public Health Dent. 2011;9(5):336-40.
Siddique AB, Rahman SMM, Hossain MA, Rashid MA. Phytochemical screening and comparative antimicrobial potential of different extracts of Stevia rebaudiana Bertoni leaves. Asian Pac J Trop Dis. 2014;4(4):275-80.
Subramaniam R, Mittal S, Hiregoudar M, Ratan G, Sakeenabi B, Prashant G, et al. Antimicrobial activity of Stevioside on periodontal pathogens and Candida albicans - An invitro study. Indian Assoc Public Health Dent. 2011;9(5):325.
Muanda FN, Soulimani R, Diop B, Dicko A. Study on chemical composition and biological activities of essential oil and extracts from Stevia rebaudiana Bertoni leaves. LWT-Food Sci Technol. 2011;44(9):1865-72.
Bhimba BV, Meenupriya J, Joel EL, Naveena DE, Kumar S, Thangaraj M. Antibacterial activity and characterization of secondary metabolites isolated from mangrove plant Avicennia officinalis. Asian Pac J Trop Med. 2010;3(7):544-6.
Sharon V, Fazel N. Oral candidiasis and angular cheilitis. Dermatol ther. 2010;23(3):230-42.
Niimi M, Firth NA, Cannon RD. Antifungal drug resistance of oral fungi. Odontology. 2010;98(1):15-25.
Hossain MA, Siddique A, Rahman SM, Hossain M. Chemical composition of the essential oils of Stevia rebaudiana Bertoni leaves. Asian J Tradit Med. 2010;5(2):56-61.
Lemus-Mondaca R, Vega-Gálvez A, Zura-Bravo L, Ah-Hen K. Stevia rebaudiana Bertoni, source of a high-potency natural sweetener: A comprehensive review on the biochemical, nutritional and functional aspects. Food Chem. 2012;132(3):1121-32.
Šic Žlabur J, Voća S, Dobričević N, Ježek D, Bosiljkov T, Brnčić M. Stevia rebaudiana Bertoni - A review of nutritional and biochemical properties of natural sweetener. Agric Conspec Sci. 2013;78(1):25-30.
Beemnet M, Weldemarlam G, Zewdinesh D. Stevia production guideline. Addis Ababa: Ethiopian Institute of Agricultural Research; 2014.
Ferrazzano GF, Cantile T, Alcidi B, Coda M, Ingenito A, Zarrelli A, et al. Is Stevia rebaudiana Bertoni a non cariogenic sweeteners? A review. Molecules. 2016;21(1):1-9.
Contreras S. Anticariogenic properties and effects on periodontal structures of Stevia rebaudiana Bertoni. Narrative review. J Oral Res. 2013;2(3):158-66.
Tarka S, Roberts A. Stevia: it's not just about calories. Open Obes J. 2010;2:101-9.
Khairoui A, Hasib A, Haiz CA, Amehra F, Bakha M, Boulli A. Stevia rebaudiana Bertoni (honey leaf): a magnificent natural bio sweetener, biochemical composition, nutritional and terapeutic values. J Nat Sci Res. 2017;7(14):75.
Goyal S, Samsher GR, Goyal R. Stevia (Stevia rebaudiana) a bio-sweetener: a review. Int J Food Sci Nutr. 2010;61(1):1-10.
Mishra, Pankaj K, Singh R, Kumar U, Piakash V. Stevia rebaudiana - A magical sweeteners. Am J Plant Sci. 2010;1(5):62-74.
Sichani MM, Karbasizadeh V, Aghai F, Mofid MR. Effect of different extracts of Stevia rebaudiana leaves on Streptococcus mutans growth. J Med Plants Res. 2012;6(32):4731-4.
Gamboa F, Chaves M. Antimicrobial potential of extract from Stevia rebaudiana leaves against bacteria of importance in dental caries. Act Odont Latinoam. 2012;2(25):171-5.
Agati G, Azzarello E, Pollastri S, Tattini M. Flavonoids as antioxidants in plants: location and functional significance. Plant Sci. 2012;196:67-76.
Aboh M, Olayinka B, Adeshina G, Oladosu P. Antifungal activities of phyto compounds from Mitracarpus villosus (Sw.) DC from Abuja, Nigeria. J Microbiol Res. 2014;4(2):86-91.
Negri M, Salci TP, Shinobu-Mesquita CS, Capoci IR, Svidzinski TI, Kioshima ES. Early state research on antifungal natural products. Molecules. 2014;19(3):2925-56.
Ahmad A, Khan A, Akhtar F, Yousuf S, Xess I, Khan L, et al. Fungicidal activity of thymol and carvacrol by disrupting ergosterol biosynthesis and membrane integrity against Candida. Eur J Clin Microbiol Infect Dis. 2011;30(1):41-50.
How to Cite
HERAWATI, Margaretha; DEVIYANTI, Sinta; FERHAD, Adibah. The Antifungal Potential of Stevia rebaudiana Bertoni Leaf Extract Against Candida albicans. Journal of Indonesian Dental Association, [S.l.], v. 4, n. 1, p. 55-60, apr. 2021. ISSN 2621-6175. Available at: <>. Date accessed: 24 apr. 2024. doi:
Review Article