Oral Squamous Cell Carcinoma in A Younger Woman with Lack of Known Risk Factors
Abstract
Background: Oral ulcer is a common oral mucosal lesion and arguably the most challenging one to manage because of its various predisposing factors. The public refers to all types of ulcers in the oral cavity as stomatitis, although it can lead to various diagnoses, including malignancy. Case Presentation: This case report aims to discuss obstacles in diagnosis for a case formerly underdiagnosed as stomatitis in a young adult woman with a definitive diagnosis at the end as squamous cell carcinoma of the left tongue. Case management: Initial therapy involves eliminating the infection, which is achieved through local therapy using antiseptic mouthwash combined with chlorine dioxide gel to reduce the size of the lesion and alleviate the pain. During the second visit, there was a significant improvement in the ulcer size, but the area of induration persisted. The patient was then educated and informed about the suspicion of malignancy and referred for a biopsy. Conclusion: Oral ulcer presented with induration should be managed immediately, including referral for biopsy of the lesion and symptomatic relief. Although the ulcer significantly improved in size after infection control, the induration presented should raise suspicion of malignancy, and a biopsy is mandatory to obtain a definitive diagnosis without delay.References
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15. Mathur, R., Singhavi, H. R., Malik, A., Nair, S., & Chaturvedi, P. (2019). Role of Poor Oral Hygiene in Causation of Oral Cancer-a Review of Literature. Indian journal of surgical oncology, 10(1), 184–195.
16. Rodríguez-Molinero, J., Migueláñez-Medrán, B. D. C., Puente-Gutiérrez, C., Delgado-Somolinos, E., Martín Carreras-Presas, C., Fernández-Farhall, J., & López-Sánchez, A. F. (2021). Association between Oral Cancer and Diet: An Update. Nutrients, 13(4), 1299. https://doi.org/10.3390/nu13041299
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18. Budhy, T.I., Soemaryono B., Aprilia U., (2015). Penentuan Grading Tumor Ganas Oral Squamous Cell Carcinoma Berdasarkan Gambaran Histopatologi. Jurnal Biosains Pascasarjana 17, 46. https://doi.org/10.20473/jbp.v17i1.2015.46-51
19. Lin, N. C., Hsu, J. T., Tsai, K. Y. (2020). Survival and clinicopathological characteristics of different histological grades of oral cavity squamous cell carcinoma: A single-center retrospective study. PloS one, 15(8), e0238103. https://doi.org/10.1371/journal.pone.0238103
2. Zakiawati, D., Nur'Aeny, N., Setiadhi, R., 2020. Distribution of oral ulceration cases in Oral Medicine Integrated Installation of Universitas Padjadjaran Dental Hospital. Padjadjaran Journal of Dentistry 32, 237.
3. Violeta, B.V., Hartomo, B.T., 2020. Tata Laksana Perawatan Ulkus Traumatik pada Pasien Oklusi Traumatik: Laporan Kasus. e-GiGi 8. https://doi.org/10.35790/eg.8.2.2020.30633).
4. Fung SY, Lam JW, Chan KC. Clinical utility of circulating Epstein-Barr virus DNA analysis for the management of nasopharyngeal carcinoma. Chin Clin Oncol. 2016 Apr;5(2):18. doi: 10.21037/cco.2016.03.07. PMID: 27121878
5. Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet. 2019 Jul 6;394(10192):64-80. doi: 10.1016/S0140-6736(19)30956-0. Epub 2019 Jun 6. PMID: 31178151.
6. Tan Y, Wang Z, Xu M, Li B, Huang Z, Qin S, Nice EC, Tang J, Huang C. Oral squamous cell carcinomas: state of the field and emerging directions. Int J Oral Sci. 2023 Sep 22;15(1):44. doi: 10.1038/s41368-023-00249-w. PMID: 37736748; PMCID: PMC10517027.
7. Fatima J, Fatima E, Mehmood F, Ishtiaq I, Khan MA, Khurshid HMS, Kashif M. Comprehensive Analysis of Oral Squamous Cell Carcinomas: Clinical, Epidemiological, and Histopathological Insights with a Focus on Prognostic Factors and Survival Time. Cureus. 2024 Feb 18;16(2):e54394. doi: 10.7759/cureus.54394. PMID: 38505442; PMCID: PMC10949903.
8. Farshadpour F, Hordijk GJ, Koole R, Slootweg PJ. Non-smoking and non-drinking patients with head and neck squamous cell carcinoma: a distinct population. Oral Dis. 2007 Mar;13(2):239-43. doi: 10.1111/j.1601-0825.2006.01274.x. PMID: 17305629.
9. Kruse, A. L., Bredell, M., & Grätz, K. W. (2010). Oral squamous cell carcinoma in non-smoking and non-drinking patients. Head & neck oncology, 2, 24. https://doi.org/10.1186/1758-3284-2-24.
10. Moyses, R. A., López, R. V., Cury, P. M., Siqueira, S. A., Curioni, O. A., Gois Filho, J. F., Figueiredo, D. L., Head and Neck Genome Project GENCAPO, Tajara, E. H., & Michaluart, P., Jr (2013). Significant differences in demographic, clinical, and pathological features in relation to smoking and alcohol consumption among 1,633 head and neck cancer patients. Clinics (Sao Paulo, Brazil), 68(6), 738–744.
11. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4. PMID: 33538338.
12. Wolfer S, Kunzler A, Foos T, Ernst C, Leha A, Schultze-Mosgau S. Gender and risk-taking behaviours influence the clinical presentation of oral squamous cell carcinoma. Clin Exp Dent Res. 2022 Feb;8(1):141-151. doi: 10.1002/cre2.523. Epub 2022 Jan 5. PMID: 34989151; PMCID: PMC8874093.
13. Shahaf Givony. Oral squamous cell carcinoma (OSCC) an overview. Medical Sciences, 2020, Vol. 8 (13), pp. 67-74. e-ISSN: 2345-0592. Available online at www.medicsciences.com.
14. Carreras-Torras C, Gay-Escoda C. Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review. Med Oral Patol Oral Cir Bucal. 2015 May 1;20(3):e305-15. doi: 10.4317/medoral.20347. PMID: 25662554; PMCID: PMC4464918.
15. Mathur, R., Singhavi, H. R., Malik, A., Nair, S., & Chaturvedi, P. (2019). Role of Poor Oral Hygiene in Causation of Oral Cancer-a Review of Literature. Indian journal of surgical oncology, 10(1), 184–195.
16. Rodríguez-Molinero, J., Migueláñez-Medrán, B. D. C., Puente-Gutiérrez, C., Delgado-Somolinos, E., Martín Carreras-Presas, C., Fernández-Farhall, J., & López-Sánchez, A. F. (2021). Association between Oral Cancer and Diet: An Update. Nutrients, 13(4), 1299. https://doi.org/10.3390/nu13041299
17. Rivera C, Venegas B. Histological and molecular aspects of oral squamous cell carcinoma (Review). Oncol Lett. 2014 Jul;8(1):7-11. doi: 10.3892/ol.2014.2103. Epub 2014 Apr 29. PMID: 24959211; PMCID: PMC4063640.
18. Budhy, T.I., Soemaryono B., Aprilia U., (2015). Penentuan Grading Tumor Ganas Oral Squamous Cell Carcinoma Berdasarkan Gambaran Histopatologi. Jurnal Biosains Pascasarjana 17, 46. https://doi.org/10.20473/jbp.v17i1.2015.46-51
19. Lin, N. C., Hsu, J. T., Tsai, K. Y. (2020). Survival and clinicopathological characteristics of different histological grades of oral cavity squamous cell carcinoma: A single-center retrospective study. PloS one, 15(8), e0238103. https://doi.org/10.1371/journal.pone.0238103
Published
2025-07-24
How to Cite
SARI, Dwi Kartika; SOEWONDO, Maria Bernadeth Isidora Karsini.
Oral Squamous Cell Carcinoma in A Younger Woman with Lack of Known Risk Factors.
Journal of Indonesian Oral Medicine Society, [S.l.], v. 2, n. 3, p. 1-7, july 2025.
ISSN 3026-6688.
Available at: <http://jurnal.pdgi.or.id/index.php/jioms/article/view/1369>. Date accessed: 24 aug. 2025.
doi: https://doi.org/10.32793/jioms.v2i3.1369.
Section
Case Reports

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