An Occurence of Oral Allergic Reactions in Patients with Illnes Anxiety Disorder

An Imaginary Illness Turns into Real Lesions

  • Rahmi Amtha Oral Medicine Department, Faculty of Dentistry, Trisakti University, Jakarta, Indonesia
  • Endah Ayu Tri Wulandari Oral Medicine Division, Dentistry Department, Cipto Mangunkusumo General Hospital/ Faculty of Medicine University of Indonesia, Jakarta, Indonesia


Background Allergic reaction affects up to 30% of the world’s population, with underlying pathophysiology involving immunoregulatory dysfunctions and the most common oral symptom is ulceration. Case Description A 33-year-old male patient did doctor shopping of Oral Medicine Specialists in Jakarta with the fear of having oral cancer and was diagnosed of hypochondriasis by psychiatrist. The patient noticed a small irregular red macule on the palate that grew wider every day. There was no pain, bleeding or migration of lesion reported. Hematology profile showed an increased level of Immunoglobulin E (IgE). The red macule completely resolved after administration of Loratadine 10 mg once daily for a month. The patient was educated for routine oral check-up and psychiatry consultation. Conclusion Hypochondriasis may cause immunoregulatory imbalance by modulating Th2 cytokines system that is responsible in IgE level and may produce the unspecific oral manifestation which gave positive response with antihistamine drug.


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How to Cite
AMTHA, Rahmi; TRI WULANDARI, Endah Ayu. An Occurence of Oral Allergic Reactions in Patients with Illnes Anxiety Disorder. Journal of Indonesian Oral Medicine Society, [S.l.], v. 1, n. 1, p. 1-7, nov. 2023. ISSN 3026-6688. Available at: <>. Date accessed: 22 apr. 2024.
Case Reports