Radiographic evaluation of the healing process of alveolar abscess through regulation of VEGF and angiogenesis
Abstract
Objectives: This review article aims to explain how the regulation of vascular endothelial growth factor (VEGF) and angiogenesis on alveolar abscess healing process evaluation using radiograph.Review: The databases used in this review are Google Scholar, PubMed, and Science Direct. A total of 1280 search results appeared based on keywords. The search results were selected by title and abstract according to their relevance to the review topic. A total of 24 literatures were reviewed. The alveolar bone destruction is one of the signs of an inflammatory lesion in the alveolar bone. Bone damage that occurs in cases of the abscess will reduce the absorption of x-rays thereby giving a radiolucent appearance on radiographic examination. A radiographic examination is a supporting examination that can be used to develop the healing process. The processes of angiogenesis and osteogenesis of bone homeostasis will complement each other for the bone healing process, while VEGF is a growth factor that can increase the expression of BMPs and osteoblast differentiation so that the bone healing process can take place properly.
Conclusion: VEGF plays a significant role in both bone healing and regulation of vascular development and angiogenesis. However, excessive VEGF can also be harmful to the process of bone repair because it can stimulate the recruitment of osteoclasts. Therefore, VEGF regulation has an important role in apical abscess healing, and radiographic images that are quantitatively analyzed can be used to quantify this healing process.
References
Metzger Z, Kfir A. Healing of Apical Lesions: How Do They Heal, Why Does the Healing Take So Long, and Why Do Some Lesions Fail to Heal? Disinfect. Root Canal Syst. Treat. Apical Periodontitis. 2014;15:297–318.
Tartuk GA, Bulut ET. The effects of periapical lesion healing on bone density. Int. Dent. Res. 2020;10:90–9.
Kaya S, Yavuz I, Uysal I, Akkuş Z. Measuring bone density in healing periapical lesions by using cone beam computed tomography: a clinical investigation. J Endod. 2012;38(1):28-31.
Devescovi V, Leonardi E, Ciapetti G, Cenni E. Growth factors in bone repair. Chir Organi Mov. 2008;92(3):161-8.
Liu Y, Berendsen AD, Jia S, Lotinun S, Baron R, Ferrara N, Olsen BR. Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest. 2012;122(9):3101-13.
Zhang H, Kot A, Lay YE, Fierro FA, Chen H, Lane NE, Yao W. Acceleration of Fracture Healing by Overexpression of Basic Fibroblast Growth Factor in the Mesenchymal Stromal Cells. Stem Cells Transl Med. 2017;6(10):1880-93.
Gómez-Gaviro MV, Lovell-Badge R, Fernández-Avilés F, Lara-Pezzi E. The vascular stem cell niche. J Cardiovasc Transl Res. 2012;5(5):618-30.
Stegen S, van Gastel N, Carmeliet G. Bringing new life to damaged bone: the importance of angiogenesis in bone repair and regeneration. Bone. 2015;70:19-27.
White SC, Pharoah MJ. Oral Radiology-E-Book: Principles and Interpretation. Elsevier Health Sciences; 2014.
Jaswal S, Patil N, Singh MP, Dadarwal A, Sharma V, Sharma AK. A Comparative Evaluation of Digital Radiography and Ultrasound Imaging to Detect Periapical Lesions in the Oral Cavity. Cureus. 2022 Oct 8;14(10):e30070.
Huang CC, Chen JC, Chang YC, Jeng JH, Chen CM. A fractal dimensional approach to successful evaluation of apical healing. Int Endod J. 2013;46(6):523-9.
Fitriandari BQ, Pramanik F, Adang RAF. Proses penyembuhan lesi periapikal pada radiografi periapikal menggunakan Software Image J. Padjadjaran J. Dent. Res. Students. 2018;2:116–24.
Claes L, Recknagel S, Ignatius A. Fracture healing under healthy and inflammatory conditions. Nat Rev Rheumatol. 2012;8(3):133-43.
Gómez-Barrena E, Rosset P, Lozano D, Stanovici J, Ermthaller C, Gerbhard F. Bone fracture healing: cell therapy in delayed unions and nonunions. Bone. 2015;70:93-101.
Yang YQ, Tan YY, Wong R, Wenden A, Zhang LK, Rabie AB. The role of vascular endothelial growth factor in ossification. Int J Oral Sci. 2012;4(2):64-8.
Hu K, Olsen BR. Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair. J Clin Invest. 2016;126(2):509-26.
Diomede F, Marconi GD, Fonticoli L, Pizzicanella J, Merciaro I, Bramanti P, Mazzon E, Trubiani O. Functional Relationship between Osteogenesis and Angiogenesis in Tissue Regeneration. Int J Mol Sci. 2020;21(9):3242.
Hu K, Olsen BR. The roles of vascular endothelial growth factor in bone repair and regeneration. Bone. 2016;91:30-8.
Jin SW, Sim KB, Kim SD. Development and Growth of the Normal Cranial Vault : An Embryologic Review. J Korean Neurosurg Soc. 2016;59(3):192-6.
Amer ME, Heo MS, Brooks SL, Benavides E. Anatomical variations of trabecular bone structure in intraoral radiographs using fractal and particles count analyses. Imaging Sci Dent. 2012;42(1):5-12.
Soğur E, Baksı BG, Gröndahl HG, Sen BH. Pixel intensity and fractal dimension of periapical lesions visually indiscernible in radiographs. J Endod. 2013;39(1):16-9.
Huang B, Wang W, Li Q, Wang Z, Yan B, Zhang Z, Wang L, Huang M, Jia C, Lu J, Liu S, Chen H, Li M, Cai D, Jiang Y, Jin D, Bai X. Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone. Nat Commun. 2016;7:13885.
Ballmer-Hofer K. Vascular Endothelial Growth Factor, from Basic Research to Clinical Applications. Int J Mol Sci. 2018;19(12):3750.
Saeed S, Ibraheem UM, Alnema M. Quantitative analysis by pixel intensity and fractal dimensions for imaging diagnosis of periapical lesions. Int. J. Enhanc. Res. Sci. Technol. Eng. 2019;3:138–44.
Mosquera-Barreiro C, Ruíz-Piñón M, Sans FA, Nagendrababu V, Vinothkumar TS, Martín-González J, Martín-Biedma B, Castelo-Baz P. Predictors of periapical bone healing associated with teeth having large periapical lesions following nonsurgical root canal treatment or retreatment: A cone beam computed tomography-based retrospective study. Int Endod J. 2024;57(1):23-36.
Tartuk GA, Bulut ET. The effects of periapical lesion healing on bone density. Int. Dent. Res. 2020;10:90–9.
Kaya S, Yavuz I, Uysal I, Akkuş Z. Measuring bone density in healing periapical lesions by using cone beam computed tomography: a clinical investigation. J Endod. 2012;38(1):28-31.
Devescovi V, Leonardi E, Ciapetti G, Cenni E. Growth factors in bone repair. Chir Organi Mov. 2008;92(3):161-8.
Liu Y, Berendsen AD, Jia S, Lotinun S, Baron R, Ferrara N, Olsen BR. Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest. 2012;122(9):3101-13.
Zhang H, Kot A, Lay YE, Fierro FA, Chen H, Lane NE, Yao W. Acceleration of Fracture Healing by Overexpression of Basic Fibroblast Growth Factor in the Mesenchymal Stromal Cells. Stem Cells Transl Med. 2017;6(10):1880-93.
Gómez-Gaviro MV, Lovell-Badge R, Fernández-Avilés F, Lara-Pezzi E. The vascular stem cell niche. J Cardiovasc Transl Res. 2012;5(5):618-30.
Stegen S, van Gastel N, Carmeliet G. Bringing new life to damaged bone: the importance of angiogenesis in bone repair and regeneration. Bone. 2015;70:19-27.
White SC, Pharoah MJ. Oral Radiology-E-Book: Principles and Interpretation. Elsevier Health Sciences; 2014.
Jaswal S, Patil N, Singh MP, Dadarwal A, Sharma V, Sharma AK. A Comparative Evaluation of Digital Radiography and Ultrasound Imaging to Detect Periapical Lesions in the Oral Cavity. Cureus. 2022 Oct 8;14(10):e30070.
Huang CC, Chen JC, Chang YC, Jeng JH, Chen CM. A fractal dimensional approach to successful evaluation of apical healing. Int Endod J. 2013;46(6):523-9.
Fitriandari BQ, Pramanik F, Adang RAF. Proses penyembuhan lesi periapikal pada radiografi periapikal menggunakan Software Image J. Padjadjaran J. Dent. Res. Students. 2018;2:116–24.
Claes L, Recknagel S, Ignatius A. Fracture healing under healthy and inflammatory conditions. Nat Rev Rheumatol. 2012;8(3):133-43.
Gómez-Barrena E, Rosset P, Lozano D, Stanovici J, Ermthaller C, Gerbhard F. Bone fracture healing: cell therapy in delayed unions and nonunions. Bone. 2015;70:93-101.
Yang YQ, Tan YY, Wong R, Wenden A, Zhang LK, Rabie AB. The role of vascular endothelial growth factor in ossification. Int J Oral Sci. 2012;4(2):64-8.
Hu K, Olsen BR. Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair. J Clin Invest. 2016;126(2):509-26.
Diomede F, Marconi GD, Fonticoli L, Pizzicanella J, Merciaro I, Bramanti P, Mazzon E, Trubiani O. Functional Relationship between Osteogenesis and Angiogenesis in Tissue Regeneration. Int J Mol Sci. 2020;21(9):3242.
Hu K, Olsen BR. The roles of vascular endothelial growth factor in bone repair and regeneration. Bone. 2016;91:30-8.
Jin SW, Sim KB, Kim SD. Development and Growth of the Normal Cranial Vault : An Embryologic Review. J Korean Neurosurg Soc. 2016;59(3):192-6.
Amer ME, Heo MS, Brooks SL, Benavides E. Anatomical variations of trabecular bone structure in intraoral radiographs using fractal and particles count analyses. Imaging Sci Dent. 2012;42(1):5-12.
Soğur E, Baksı BG, Gröndahl HG, Sen BH. Pixel intensity and fractal dimension of periapical lesions visually indiscernible in radiographs. J Endod. 2013;39(1):16-9.
Huang B, Wang W, Li Q, Wang Z, Yan B, Zhang Z, Wang L, Huang M, Jia C, Lu J, Liu S, Chen H, Li M, Cai D, Jiang Y, Jin D, Bai X. Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone. Nat Commun. 2016;7:13885.
Ballmer-Hofer K. Vascular Endothelial Growth Factor, from Basic Research to Clinical Applications. Int J Mol Sci. 2018;19(12):3750.
Saeed S, Ibraheem UM, Alnema M. Quantitative analysis by pixel intensity and fractal dimensions for imaging diagnosis of periapical lesions. Int. J. Enhanc. Res. Sci. Technol. Eng. 2019;3:138–44.
Mosquera-Barreiro C, Ruíz-Piñón M, Sans FA, Nagendrababu V, Vinothkumar TS, Martín-González J, Martín-Biedma B, Castelo-Baz P. Predictors of periapical bone healing associated with teeth having large periapical lesions following nonsurgical root canal treatment or retreatment: A cone beam computed tomography-based retrospective study. Int Endod J. 2024;57(1):23-36.
Published
2024-08-20
How to Cite
ASYKARIE, Ichda Nabiela Amiria; EPSILAWATI, Lusi.
Radiographic evaluation of the healing process of alveolar abscess through regulation of VEGF and angiogenesis.
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI), [S.l.], v. 8, n. 2, p. 73-78, aug. 2024.
ISSN 2686-1321.
Available at: <http://jurnal.pdgi.or.id/index.php/jrdi/article/view/1188>. Date accessed: 14 oct. 2024.
doi: https://doi.org/10.32793/jrdi.v8i2.1188.
Section
Review Article
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
