Differences between calcifying epithelial odontogenic tumor and calcifying odontogenic cyst through panoramic radiograph: a scoping review

  • Regrina Setiawan Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia, 40132
  • Ria Noerianingsih Firman Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia, 40132
  • Lusi Epsilawati Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia, 40132 http://orcid.org/0000-0002-3221-747X

Abstract

Objectives: This review article is aimed to describe the radiographic features of CEOT and COC to determine the differences between the two lesions on panoramic radiographs.
Review: This research is a descriptive study using scoping review method based on the Preferred Reporting Items for Systematic Review and Meta-analysis for Scoping Review (PRISMA-Scr). This study examines English and Indonesian articles of CEOT and COC with panoramic radiography as a diagnostic tool published in 2015 – 2021. Relevant articles were obtained from searches using keywords and inclusion criteria on PubMed, PMC NCBI, and hand searching techniques. A total of 32 articles were identified at initial study identification. Duplication, title and abstract, and full-text inspection consecutively excluded 1, 3, and 8 articles. A total of 20 eligible articles were included in this study, 10 cases of Calcifying Epithelial Odontogenic Tumor and 10 cases of Calcifying Odontogenic Cyst.
Conclusion: The differences between COC and CEOT on panoramic radiographs are COC is more commonly found in the anterior region than CEOT and COC tends to occur in the periapical or lateral part of adjacent teeth and causes root resorption, whereas CEOT tends to be located at the crown of impacted teeth. There aren’t any pathognomonic radiographic findings from the CEOT and COC, so a definitive diagnosis still requires histopathological analysis.

Author Biographies

Regrina Setiawan, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia, 40132
Undergraduate Student
Ria Noerianingsih Firman, Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia, 40132
Staff
Lusi Epsilawati, Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia, 40132
Staff

References

Sinha T. Tumors: Benign and Malignant. Cancer Ther Oncol Int J. 2018;10(3):1–3.
Kanaco M, Pontoh V, Sunaryo H. Pola tumor rongga mulut di Rsup Prof.Dr.R.D Kandou Manado periode 2014-2016. e-CliniC. 2016;4(2).
Halder B, Halder NR. Histopathological Study of Tumor and Tumor Like Lesions of the Oral Cavity. Ann Pathol Lab Med. 2019;6(4):A248-252.
Lee SK, Kim YS. Current concepts and occurrence of epithelial odontogenic tumors: II. Calcifying epithelial odontogenic tumor versus ghost cell odontogenic tumors derived from calcifying odontogenic cyst. Korean J Pathol. 2014;48(3):175–87.
Ide F, Kikuchi K, Miyazaki Y, Kusama K, Saito I, Muramatsu T. The Early History of Odontogenic Ghost Cell Lesions: From Thoma to Gorlin. Head Neck Pathol. 2015;9(1):74–8.
Siriwardena BSMS, Speight PM, Franklin CD, Abdelkarim R, Khurram SA, Hunter KD. CEOT Variants or Entities: Time for a Rethink? A Case Series with Review of the Literature. Head Neck Pathol. 2021 Mar;15(1):186-201.
White SC, Pharoah MJ. Oral Radiology: Principles and Interpretation. 7th ed. St. Louis: Mosby/Elsevier; 2014. p.271-284.
de Arruda JAA, Monteiro JLGC, Abreu LG, de Oliveira Silva LV, Schuch LF, de Noronha MS, et al. Calcifying odontogenic cyst, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma: A systematic review. J Oral Pathol Med. 2018;47(8):721–30.
Siwach P, Joy T, Tupkari J, Thakur A. Controversies in Odontogenic Tumours Review. Sultan Qaboos Univ Med J. 2017;17(3):268–76.
Wright JM, Odell EW, Speight PM, Takata T. Odontogenic Tumors, WHO 2005: Where Do We Go from Here? Head Neck Pathol. 2014;8(4):373–82.
Soluk-Tekkeşin M, Wright JM. The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2017 (4th) Edition. Turk Patoloji Derg. 2018;34(1).
Speight PM, Takata T. New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours. Virchows Arch. 2018;472(3):331–9.
Van der Woude H, Smithuis R. Bone Tumor - Systematic Approach and Differential Diagnosis. 2010;21:1.
1Mehta K, McBee MP, Mihal DC, England EB. Radiographic Analysis of Bone Tumors: A Systematic Approach. Semin Roentgenol [Internet]. 2017;52(4):194–208.
Pillai KG. Oral and Maxillofacial Radiology Basic Principles and Interpretation. First. Jaypee Brothers; 2015.
Eshghyar N, Jalayer-Nadery N, Ashery R. Calcifying odontogenic cyst: An analysis of thirty-six cases. Acta Med Iran. 2012;44(1):59–62.
Chrcanovic BR, Gomez RS. Calcifying epithelial odontogenic tumor: An updated analysis of 339 cases reported in the literature. J Cranio-Maxillofacial Surg [Internet]. 2017;45(8):1117–23.
Yang H, Jo E, Kim HJ, Cha I, Jung Y-S, Nam W, et al. Deep Learning for Automated Detection of Cyst and Tumors of the Jaw in Panoramic Radiographs. J Clin Med. 2020;9(6):1839.
19. Whaites E, Hons BDS, Edin F, Eng F. Essentials of Dental Radiography and Radiology (Sixth Edition). 2020;117.
Sharma U, Gulati A, Batra H, Singh D. Calcifying Epithelial Odontogenic Tumor in Anterior Maxilla Associated with a Supernumerary Tooth: a Case Report. J Dent Res Dent Clin Dent Prospects. 2013;7(1):51–514.
Singh N, Sahai S, Singh S, Singh S. Calcifying epithelial odontogenic tumor (Pindborg tumor). Natl J Maxillofac Surg [Internet]. 2011;2(2):225–7.
de Moraes ATL, Soares HA, Viana Pinheiro J de J, Ribeiro Ribeiro AL. Marsupialization before enucleation as a treatment strategy for a large calcifying odontogenic cyst: Case report. Int J Surg Case Rep. 2020;67:239–44.
de Arruda JAA, Arantes DAC, Schuch LF, Mosconi C, Abreu LG, de Andrade BAB, et al. A Rare Case of an Aggressive Clear Cell Variant of Calcifying Epithelial Odontogenic Tumor in the Posterior Maxilla. Int J Surg Pathol. 2020;28(5):526–35.
Badruddin Bin Ghazali A. Interpreting panoramic radiographs for beginners. BDJ Student. 2020;27(3):49.
Bhat S, Shetty SR, Babu SG, Shetty P, Ka F. A rare variant of calcifying odontogenic cyst with ameloblastoma presentation. Stomatologija. 2015;17(4):131–4
Shah U, Patel H, Pandya H, Dewan D, Bhavsar B, Steward and E. Ameloblastomatous Calcifying Odontogenic Cyst: A Rare Entity. Ann Maxillofac Surg. 2018;8(1):121–3.
Aristizabal Arboleda P, Sánchez-Romero C, de Almeida OP, Flores Alvarado SA, Martínez Pedraza R. Calcifying Odontogenic Cyst Associated With Dentigerous Cyst in a 15-Year-Old Girl. Int J Surg Pathol. 2018 Dec;26(8):758–65.
Uzun T, Çinpolat E. Calcifying odontogenic cyst associated with the impacted third molar: A case report. Pan Afr Med J. 2019;33:1–5.
Santos HB de P, de Morais EF, Moreira DGL, Neto LF de A, Gomes PP, Freitas R de A. Calcifying Odontogenic Cyst with Extensive Areas of Dentinoid: Uncommon Case Report and Update of Main Findings. Case Rep Pathol. 2018;2018:1–4.
Turatti E, Brasil J, de Andrade BAB, Romañach MJ, de Almeida OP. Clear Cell Variant of Calcifying Epithelial Odontogenic Tumor: Case Report with Immunohistochemical Findings. J Clin Exp Dent. 2015;7(1):163–6.
Rydin K, Sjöström M, Warfvinge G. Clear cell variant of intraosseous calcifying epithelial odontogenic tumor: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol [Internet]. 2016;122(4):125–30.
Mahdavi N, Kardooni Khoozestani N, Hasheminasab M, Soltani N. Hybrid Odontogenic Tumor of Calcifying Odontogenic Cyst and Ameloblastic Fibroma: a Case Report and Review of Literature. J Dent (Shiraz). 2020;21(2):153–7.
More CB, Vijayvargiya R. Intraosseous calcifying epithelial odontogenic (Pindborg) tumor: A rare entity. J Oral Maxillofac Pathol. 2015;19(2):269.
Sánchez-Romero C, Carlos R, de Almeida OP, Romañach MJ. Microcystic Calcifying Epithelial Odontogenic Tumor. Head Neck Pathol [Internet]. 2018;12(4):598–603.
Ibituruna ACH, Costa ARGF, Paulo LFB de, Faria PR de, Cardoso SV, Loyola AM. Multiple calcifying epithelial odontogenic tumor: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;128(3):268–72.
Santosh N, McNamara KK, Kalmar JR, Iwenofu OH. Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor: A Distinct Entity with Predilection for Anterior Maxilla. Head Neck Pathol [Internet]. 2019;13(4):718–21.
Costa LCMC, Neto JBM, Eliene-Magda de-Assis, Gomes HE, Leitão TJ, Vasconcelos RRC, et al. Peripheral Calcifying Odontogenic Cyst: A rare case report. J Clin Exp Dent. 2018;10(11):e1140–4.
Só BB, Carrard VC, Hildebrand L de C, Martins MAT, Martins MD. Synchronous Calcifying Epithelial Odontogenic Tumor: Case Report and Analysis of the 5 Cases in the Literature. Head Neck Pathol [Internet]. 2020;14(2):435–41.
Gülşen U, Dereci Ö, Gülşen EA. Treatment of a calcifying epithelial odontogenic tumour with tube decompression: a case report. Br J Oral Maxillofac Surg. 2018 Dec;56(10):979–81.
Channappa NK, Krishnapillai R, Rao JBM. Unusual Cystic Variant of Calcifying Epithelial Odontogenic Tumor. J Investig Clin Dent. 2020;3(2):152–6.
Sheikh J, Cohen MD, Ramer N, Payami A. Ghost Cell Tumors. J Oral Maxillofac Surg [Internet]. 2017;75(4):750–8.
Neuman AN, Montague L, Cohen D, Islam N, Bhattacharyya I. Report of Two Cases of Combined Odontogenic Tumors: Ameloblastoma with Odontogenic Keratocyst and Ameloblastic Fibroma with Calcifying Odontogenic Cyst. Head Neck Pathol [Internet]. 2015;9(3):417–20.
Philipsen HP, Reichart PA. Calcifying epithelial odontogenic tumour: Biological profile based on 181 cases from the literature. Oral Oncol. 2000;36(1):17–26.
Zornosa X, Müller S. Calcifying Cystic Odontogenic Tumor. Head Neck Pathol. 2010;4(4):292–4.
Uchiyama Y, Akiyama H, Murakami S, Koseki T, Kishino M, Fukuda Y, et al. Calcifying Cystic Odontogenic Tumour: CT Imaging. Br J Radiol. 2012;85(1013):548–54.
Martins MAT, Martins MD, Marques MM, Russadori SK, Lascala CA. Expansive lesion of the anterior mandible in child a case report of calcifying cystic odontogenic tumor. RPG, Rev Pós-gr [Internet]. 2011;18(3):176–81.
Akay MC, Tetik A, Zeytinoglu M. The calcifying epithelial odontogenic tumor: A case report. Int J Oral Surg. 2014;10(Suppl. 1):37–41.
Kaushal S, Mathur SR, Vijay M, Rustagi A. Calcifying epithelial odontogenic tumor (Pindborg tumor) without calcification: A rare entity. J Oral Maxillofac Pathol 2012;16:110-2.
Published
2021-08-31
How to Cite
SETIAWAN, Regrina; FIRMAN, Ria Noerianingsih; EPSILAWATI, Lusi. Differences between calcifying epithelial odontogenic tumor and calcifying odontogenic cyst through panoramic radiograph: a scoping review. Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI), [S.l.], v. 5, n. 2, p. 80-89, aug. 2021. ISSN 2686-1321. Available at: <http://jurnal.pdgi.or.id/index.php/jrdi/article/view/698>. Date accessed: 18 nov. 2024. doi: https://doi.org/10.32793/jrdi.v5i2.698.

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