Mandibular radiomorphometry analysis of children with HIV and healthy individuals on digital panoramic radiographs by age and sex
Abstract
Objectives: The chronic systemic inflammatory process of HIV Human Immunodeficiency Virus) infection in children leads B cell activity to accelerate the osteoclastogenesis process, which results in bone alterations. Long-term usage of highly active antiretroviral medication results in decreased bone quality in HIV patients (HAART). Digital panoramic images are useful for radiomorphometric analysis of the mandibular macrostructure. Mandibular bone is a bone quality analysis that is often performed.Materials and Methods: This study comprised 86 digital panoramic radiographs of pediatric HIV patients and healthy persons. Secondary data in the form of digitized conventional panoramic radiographs of 43 pediatric HIV patients and 43 healthy individuals without clinical symptoms of HIV disease were utilized as a reference.
Results: Mandibular morphometry values by sex in children with HIV and healthy adults showed (MCI) p-value 0.009, (GMI) p-value 0.934, (GI) p-value 0.584, (Go-Co) p-value 0.090, and (Co-M) p-value 0.919. Meanwhile, the results of the study with mandibular morphometric values between children with HIV and healthy individuals index based on age revealed (MCI) p-value 0.490, (GMI) p-value 0.657, (GI) p-value 0.080, (Go-Co) p-value 0.147, (Co-M) p-value 0.158
Conclusion: Mandibular morphology differed between HIV-infected children and healthy persons as measured by digital panoramic radiographs, with changes in mandibular resorption thickness, mandibular bone width, and mandibular bone thickness. Furthermore, there were no differences in values, height, and length of the mandible, as well as variances based on age and sex.
References
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Suresh S, Kumar TS, Saraswathy P, Pani S. Periodontitis and bone mineral density among pre and post menopausal women: A comparative study. J Indian Soc Periodontol [Internet]. 2010;14(1):30.
McComsey GA, Tebas P, Shane E, Yin MT, Overton ET, Huang JS, et al. Bone Disease in HIV Infection: A Practical Review and Recommendations for HIV Care Providers. Clin Infect Dis [Internet]. 2010 Oct 15;51(8):937–46.
Bunders MJ, Frinking O, Scherpbier HJ, van Arnhem LA, van Eck-Smit BL, Kuijpers TW, et al. Bone Mineral Density Increases in HIV-Infected Children Treated With Long-term Combination Antiretroviral Therapy. Clin Infect Dis [Internet]. 2013 Feb 15;56(4):583–6.
Güerri-Fernández R, Villar-García J, Díez-Pérez A, Prieto-Alhambra D. HIV infection, bone metabolism, and fractures. Arq Bras Endocrinol Metabol [Internet]. 2014 Jul;58(5):478–83.
Epsilawati L, Firman RN, Sufiawati I, Sarifah N, Gunawan I. Linear Measurement of the Condyle Position in HIV-Infected Children and Adolescents. Dentino J Kedokt Gigi. 2020;5(1):81-4.
ED, Avcu N, Uysal S, Arslan U. Evaluation of radiomorphometric indices and bone findings on panoramic images in patients with scleroderma. Oral Surg Oral Med Oral Pathol Oral Radiol [Internet]. 2019 Jan;127(1):e23–30.
Gupta S, Sandhya J. Orthopantomographic Analysis for Assessment of Mandibular Asymmetry. J Indian Orthod Soc. 2012;46(1):33–7.
Govindraju P, Mahesh Kumar TS, Chandra P, Balaji P, Sowbhagya MB. Panoramic Radiomorphometric Indices of Mandible: Biomarker for Osteoporosis. In: Biomarkers in Bone Disease [Internet]. Springer Science+Business Media Dordrecht; 2015. p. 1–23.
Aydin U, Bulut A, Bulut OE. Assessment Of Maxillary And Mandibular Bone Quality. In: European Congress Of Radiology. 2017. 10.1594/ecr2017/C-219.
Vigan A, Zuccotti G V, Puzzovio M, Pivetti V, Zamproni I, Cerini C, et al. Tenofovir disoproxil fumarate and bone mineral density: a 60-month longitudinal study in a cohort of HIV-infected youths. Antivir Ther [Internet]. 2010;15(7):1053–8.
Pramatika B, Azhari A, Epsilawati L. Correlation between mandibular length and third molar maturation based on their radiography appearances. Padjadjaran J Dent. 2018;30(2):109.
Hazan-Molina H, Molina-Hazan V, Schendel S, Aizenbud D. Reliability of panoramic radiographs for the assessment of mandibular elongation after distraction osteogenesis procedures. Orthod Craniofac Res. 2011 Feb;14(1):25–32.
Christopher P, Watanabe A, Farman A, Gon M, Watanabe DC, Paulo J, et al. Radiographic Signals Detection of Systemic Disease . Int J Morphol. 2008;26(4):915–26.
Priminiarti M, Kiswanjaya B, Iskandar HB. Radiographic Evaluation of Osteoporosis through Detection of Jaw Bone Changes: A Simplified Early Osteoporosis Detection Effort. Makara J Heal Res. 2011 Apr 5;14(2).
Ofotokun I, McIntosh E, Weitzmann MN. HIV: Inflammation and Bone. Curr HIV/AIDS Rep. 2012 Mar 17;9(1):16–25.
Sudjaritruk T, Bunupuradah T, Aurpibul L, Kosalaraksa P, Kurniati N, Prasitsuebsai W, et al. Adverse bone health and abnormal bone turnover among perinatally HIV-infected Asian adolescents with virological suppression. HIV Med [Internet]. 2017 Apr;18(4):235–44.
A Risti Saptarini P, Riyanti E, Sufiawati I, Azhari, Sasmita IS. Level vitamin D, calcium serum and mandibular bone density in HIV/AIDS children. J Int Dent Med Res. 2017;10(2):313–7.
Vikulina T, Fan X, Yamaguchi M, Roser-Page S, Zayzafoon M, Guidot DM, et al. Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats. Proc Natl Acad Sci. 2010 Aug 3;107(31):13848–53.
Published
2022-08-31
How to Cite
RAMADHAN, Alongsyah Zulkarnaen et al.
Mandibular radiomorphometry analysis of children with HIV and healthy individuals on digital panoramic radiographs by age and sex.
Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI), [S.l.], v. 6, n. 2, p. 49-54, aug. 2022.
ISSN 2686-1321.
Available at: <http://jurnal.pdgi.or.id/index.php/jrdi/article/view/887>. Date accessed: 27 apr. 2024.
doi: https://doi.org/10.32793/jrdi.v6i2.887.
Section
Original Research Article
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
